We still use on-prem Exchange with Microsoft Office at work, and it’s really becoming a problem. Microsoft already auto adds shortcuts for 365 (which we don’t use and doesn’t work with our setup), and the “Mail” app (which also doesn’t work with out setup), and now I have to explain to people to use the regularly titled Outlook icon and not the “Outlook (new)” icon (which again, won’t work with our setup).
I’m a long-time Samba fan, but even I wouldn’t run them as DCs in a production environment.